Dr. Harikesh Wong is an Assistant Professor at the Ragon Institute and MIT, where his lab studies the design principles of the immune system. He talks about how Tregs constrain conventional T cell responses during infection, and advanced fluorescence microscopy techniques to study immune responses.
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Immunometabolism in HIV – Immunometabolic defects in colon-resident CD8+ T cells in people with HIV lead to intestinal epithelial apoptosis and disruption of intestinal barrier integrity.
T Cell Dysfunction in Tumors – Mitochondria or telomeric reactive oxygen species induce DNA damage responses driving T cell dysfunction.
Microglia-Astrocyte Crosstalk – Microglia-derived Wnts drive astrocytes to reduce their association with synapses.
Monocyte-Derived Macrophages in Tumors – Researchers identified myeloid progenitor programs that fuel pro-tumorigenic monocyte-derived macrophages.
Image courtesy of Dr. Harikesh Wong
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